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| Product Name | Kit Ligand, active (KITLG), Recombinant, Human |
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| Description | Purity ≥97% (SDS-PAGE and HPLC). Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by |
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| Size | 2ug, 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mast cell growth factor, Stem cell factor, SCF, c-Kit ligand |
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| Gene, Accession, CAS # | SCF_HUMAN, SwissProt: P21583 |
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| Catalog # | 348158 |
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| Order / More Info | Kit Ligand, active (KITLG), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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