| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | ACER1 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | WB, IHC |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Rabbit Anti-Human ACER1 polyclonal antibody for WB, IHC. Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum;corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can;trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and;sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers;regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at;the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is;highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine;(Houben et al., 2006 (PubMed 16477081); Sun et al., 2008 (PubMed 17713573)). |
|---|
| Immunogen | Recombinant Protein |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | Gene ID: 125981, UniProt: Q8TDN7 |
|---|
| Catalog # | CABT-BL180 |
|---|
| Price | |
|---|
| Order / More Info | ACER1 Antibody from CREATIVE DIAGNOSTICS |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|