| 产品详情 |
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| Product Name | AR-A014418 |
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| Description | MW: 308.3. Purity >98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (conforms). GSK3beta inhibitorPotent immunosuppressant. The rapamycin-FKBP12 complex binds to and inhibits mTOR1. Inhibits IL-2-induced activation of p70 S6 kinase2. Extends lifespan of mice3. Induces autophagy in a variety of cell lines4.Scientific Background: Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50=104 nM). Inhibits beta-amyloid-mediated neurodegeneration in hippocampal slices. Antiinflammat |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Rapamycin; Sirolimus; Fermentation product; N-[(4-Methoxyphenyl) methyl]-N'-(5-nitro-2-thiazolyl) urea] |
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| Gene, Accession, CAS # | CAS: 487021-52-3 |
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| Catalog # | MBS515047 |
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| Order / More Info | AR-A014418 from MYBIOSOURCE INC. |
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| Product Specific References | S Huang et al. Cancer Biol. Ther. 2003 2:222 2. CJ Kuo et al. Nature 1992 358:70 3. DE Harrison et al. Nature 2009 460:392 4. A Flemming et al. Nat. Chem. Biol. 2011 7:9 |
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