| 产品详情 |
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| Antigenic Specificity | FBW7 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:100-1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FBW7 Polyclonal Antibody. Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E. |
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| Immunogen | n/a |
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| Other Names | AGO, archipelago, Archipelago homolog, archipelago homolog (Drosophila), CDC4, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), F-box and WD-40 domain-containing protein 7, F-box protein FBW7, F-box protein FBX30, F-box protein SEL-10, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ11071, hAgo, hCdc4, homolog of C elegans sel-10, SEL10, SEL-10 |
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| Gene, Accession # | Entrez: 55294; Uniprot: Q969H0 |
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| Catalog # | IHC-00348 |
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| Price | |
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| Order / More Info | FBW7 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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