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Product Name | Recombinant Human Tumor susceptibility gene 101 protein (TSG101), partial |
Description | Purity > 85% as determined by SDS-PAGE. MW: 36.6kDa. Partial: 1-145aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan |
Size | 100ug |
Concentration | n/a |
Applications | RUO |
Other Names | ESCRT-I complex subunit TSG101 |
Gene, Accession, CAS # | TSG101, UniProt: Q99816 |
Catalog # | RPC23522 |
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Order / More Info | Recombinant Human Tumor susceptibility gene 101 protein (TSG101), partial from BIOMATIK |
Product Specific References | n/a |
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