| 产品详情 |
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| Antigenic Specificity | CD141 (Thrombomodulin) |
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| Clone | Phx-01 |
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| Host Species | Mouse |
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| Reactive Species | mammalian |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | IHC, Western Blot (WB), ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-CD141 (Thrombomodulin). CD141 is a 75 kD, single chain, type I membrane glycoprotein also known as thrombomodulin, TM, THRM, THBD, and fetomodulin. CD141 is an important cofactor in the protein C anticoagulant system. After binding to its ligand thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Besides anti-coagulation function, CD141 is also involved in embryonic and atherosclerotic plaque development. CD141 is an endothelial cell surface glycoprotein involved in the regulation of coagulation. Via a direct interaction with thrombin, thrombomodulin causes down-regulation of multiple pro-coagulation pathways in order to preserve the anticoagulant properties of the endothelial cell surface. |
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| Immunogen | n/a |
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| Other Names | Thrombomodulin, Fetomodulin, CD141 antigen, AHUS6, BDCA3, THPH12, THRM,MMS-176P-100 |
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| Gene, Accession # | Gene ID: 7056 |
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| Catalog # | 902101 |
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| Price | |
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| Order / More Info | CD141 (Thrombomodulin) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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