| 产品详情 |
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| Product Name | Liproxstatin-1 |
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| Description | Purity >95%. Ferroptosis is a regulated, non-apoptotic form of cell death involving the production of iron-dependent reactive oxygen species (ROS). Glutathione peroxidase 4 (Gpx4) is an essential regulator of ferroptotic cell death, playing a critical role in preventing ROS-induced lipid peroxidation. Liproxstatin-1 is an inhibitor of ferroptosis induced in mouse embryonic fibroblasts (MEFs) by Gpx4 deletion (IC50 = 22 nM). It does not interfere with apoptosis, necroptosis, or necrosis. Liproxstatin-1 also blocks ferroptosis induced by specific ferroptosis inducers, including the glutathioine-depleting agents BSO and erastin and the Gpx4 inhibitor RSL3. It is effective in vivo when administered intraperitoneally, suppressing ferroptosis in Gpx4-/- mice and in a mouse model of ischemia/reperfusion-induced liver injury. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
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| Gene, Accession, CAS # | CAS: 950455-15-9 |
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| Catalog # | LS-H8490 |
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| Price | |
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| Order / More Info | Liproxstatin-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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