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| Product Name | Recombinant Human G-protein coupled receptor 161 (GPR161), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 30kDa. Partial: 1-28aa. N-terminal GST-tagged. Homo sapiens (Human). Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | G-protein coupled receptor RE2 |
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| Gene, Accession, CAS # | GPR161, UniProt: Q8N6U8 |
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| Catalog # | RPC24051 |
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| Order / More Info | Recombinant Human G-protein coupled receptor 161 (GPR161), partial from BIOMATIK |
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| Product Specific References | n/a |
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