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| Product Name | CCL5, Recombinant, Human, aa24-91, GST-Tag (C-C Motif Chemokine 5) |
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| Description | Purity ~90% (SDS-PAGE). Choattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival t |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EoCP Eosinophil chemotactic cytokine, SIS-delta, Small-inducible cytokine A5T cell-specific protein P228, TCP228T-cell-specific protein RANTES |
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| Gene, Accession, CAS # | SwissProt: P13501 |
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| Catalog # | 372637 |
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| Order / More Info | CCL5, Recombinant, Human, aa24-91, GST-Tag (C-C Motif Chemokine 5) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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