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| Product Name | Recombinant Rat 72KDA type IV collagenase (Mmp2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 78.1kDa. Full Length of Mature Protein: 110-662aa. N-terminal 6xHis-SUMO-tagged. Rattus norvegicus (Rat). Ubiquitinous metalloproteinase that is involved in diverse functions such as rodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading Extracellular domain matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 72KDA gelatinaseGelatinase AMatrix metalloproteinase-2; MMP-2 |
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| Gene, Accession, CAS # | Mmp2, UniProt: P33436 |
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| Catalog # | RPC21673 |
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| Order / More Info | Recombinant Rat 72KDA type IV collagenase (Mmp2) from BIOMATIK |
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| Product Specific References | n/a |
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