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| Product Name | Recombinant Mouse Interleukin-33 protein (Il33) (Active) |
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| Description | Purity > 98% as determined by SDS-PAGE and HPLC. MW: 17.5kDa. Full Length of Mature Protein: 109-266aa. tag-Free. Mus musculus (Mouse). Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an alarmin, that amplifies immune responses during tissue injury.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | IL-33,; Interleukin-33109-266,] |
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| Gene, Accession, CAS # | Il33, UniProt: Q8BVZ5 |
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| Catalog # | RPC26541 |
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| Order / More Info | Recombinant Mouse Interleukin-33 protein (Il33) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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