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| Product Name | PTC1 Mutant (CCDC6-RET), Active |
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| Description | CCDC6 (1-101)-RET (713-end). MW: ~80 kDa. Description: Recombinant human RET/PTC1, the fusion protein [CCDC6 (1-101)-RET (713-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: RET/PTC1 is fused of RET and the activating CCDC6 gene by intrachromosomal paracentric inversions in chromo-some 10 (1). Likes RET/PTC3, it is the most frequent RET rearrangements in papillary thyroid carcinoma (PTC) (2), especially in radiation-induced tumours. |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay, Western Blot (WB) |
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| Other Names | [Homo sapiens coiled-coil domain containing 6, mRNA; Coiled-coil domain-containing protein 6; coiled-coil domain-containing protein 6; coiled-coil domain containing 6; Papillary thyroid carcinoma-encoded protein; Protein H4] |
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| Gene, Accession, CAS # | PTC1, Gene ID: 8030, Accession: BC036757 |
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| Catalog # | MBS515643 |
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| Order / More Info | PTC1 Mutant (CCDC6-RET), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Grieco M. et al: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 1990, 60:557-563. 2. Nikiforov YE: RET/PTC rearrangement in thyroid tumors. Endocr Pathol 2002, 13:3-16. 3. Smida J. et al: Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. Int J Cancer 1999, 80:32-38. |
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