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| Product Name | PTC3 Mutant (NCOA4-RET), Active |
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| Description | NCOA4 (1-238)-RET (713-end). MW: ~98 kDa. Description: Recombinant human RET/PTC3, the fusion protein [NCOA4 (1-238)-RET (713-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: RET/PTC3 is fused of RET and the activating NCOA4 gene by intrachromosomal paracentric inversions in chromo-some 10 (1). Likes RET/PTC1, it is the most frequent RET rearrangements in papillary thyroid carcinoma (PTC) (2), especially in radiation-induced tumours. |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay, Western Blot (WB) |
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| Other Names | [Homo sapiens nuclear receptor coactivator 4, mRNA; Nuclear receptor coactivator 4; nuclear receptor coactivator 4; nuclear receptor coactivator 4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1] |
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| Gene, Accession, CAS # | PTC3, Gene ID: 8031, Accession: BC001562 |
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| Catalog # | MBS515645 |
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| Order / More Info | PTC3 Mutant (NCOA4-RET), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Santoro M, et al: Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 1994, 9:509-516. 2. Nikiforov YE: RET/PTC rearrangement in thyroid tumors. Endocr Pathol 2002, 13:3-16. 3. Smida J. et al: Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. Int J Cancer 1999, 80:32-38. |
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