| 产品详情 |
| Edit |   |
|---|
| Product Name | Glycogen Synthase Kinase 3 beta, Recombinant, Human, His-Tag (GSK3b) |
|---|
| Description | Purified by Ni/NTA agarose chromatography (≥ 85%, Verified by SDS-PAGE and Coomassie Blue stain). Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase that was first characterized by its role in intermediary metabolism. The enzyme is the mammalian homolog of the zeste-white3 (shaggy) homeotic gene of Drosophila melanogaster and has been implicated in the regulation of the c-Jun/AP-1 transcription factor. In mammals, this protein serine kinase is encoded by two related genes called GSK-3a (51kD) and b (46kD). Genetic and biochemical evidence now indicates that GSK-3 plays a role in intracellular signaling pathways. For example, during insulin and growth factor signaling the GSK-3 beta isoform becomes phosphorylated on its N-terminal serine-9 residue, presumably by either the action of MAPKAP Kinase-1 (p90 S6 kinase, Rsk-2) or p70 S6 kinase. Such phosphorylation of GSK-3 blocks its ability to phosphorylate c-Jun, protein phosphatase inhibitor 2 or the GSK-3 substrate peptide. |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Accession: NM_002093.2, SwissProt: P49841 |
|---|
| Catalog # | G8170-46 |
|---|
| Price | |
|---|
| Order / More Info | Glycogen Synthase Kinase 3 beta, Recombinant, Human, His-Tag (GSK3b) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|