| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human Exportin-2 (CSE1L), partial |
|---|
| Description | Purity > 90% as determined by SDS-PAGE. MW: 39.1kDa. Partial: 1-200aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter |
|---|
| Gene, Accession, CAS # | CSE1L, UniProt: P55060 |
|---|
| Catalog # | RPC20718 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human Exportin-2 (CSE1L), partial from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|