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| Product Name | Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 110.3kDa. Extracellular Domain: 20-764aa. N-terminal GST-tagged. Homo sapiens (Human). Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and bryonic hatopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmbrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Fetal liver kinase 1; FLK-1Kinase insert domain receptor; KDRProtein-tyrosine kinase receptor flk-1; CD309 |
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| Gene, Accession, CAS # | KDR, UniProt: P35968 |
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| Catalog # | RPC21557 |
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| Order / More Info | Recombinant Human Vascular endothelial growth factor receptor 2 (KDR), partial from BIOMATIK |
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| Product Specific References | n/a |
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