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| Product Name | CD115, Recombinant, Human, Fc Chimera (c-fms, Fms, CSF-1R, M-CSFR) |
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| Description | Purity ~95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. CD115 is also known as c-fms, marcophage colony stimulating factor receptor, or CSF-1R. It exists in immature (gp130 c-fms) and mature (gp150 c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain. A DNA sequence encoding the extracellular domain of human M-CSF R (c-fms) (aa residue 1-512) (Coussens, L. et al., 1986, Nature 320:277-280) was fused to the carboxy-terminal 6X histidine tagged Fc region of human IgG1 via a ploypeptide linker. The chimeric protein was expressed in a mouse myeloma cell line, NSO. Recombinant human M-C |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: CAA27300 |
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| Catalog # | C2447-52E |
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| Order / More Info | CD115, Recombinant, Human, Fc Chimera (c-fms, Fms, CSF-1R, M-CSFR) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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