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| Product Name | SB 203580 |
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| Description | MW: 377.4. Purity >98% (TLC); NMR (Conforms). A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38b2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38g and d at 10 mM2. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function3. |
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| Size | 10 mg, 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole] |
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| Gene, Accession, CAS # | CAS: 152121-47-6 |
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| Catalog # | MBS515033 |
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| Order / More Info | SB 203580 from MYBIOSOURCE INC. |
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| Product Specific References | 1. A Cuenda et al. FEBS Lett. 1995 364:229 2. SP Davies et al. Biochem. J. 2000 351:95 3. AM Badger et al. J. Pharmacol. Exp. Ther. 1996 279:1453 |
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