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| Product Name | NU 7441 |
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| Description | Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%. Purity 99%. MW (observed): 413.49 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one. KU 57788 |
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| Gene, Accession, CAS # | CAS: 503468-95-9 |
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| Catalog # | 3712/50 |
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| Order / More Info | NU 7441 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 20538857, 21552324, 21680529, 22140550, 22377908, 22869596, 23045526, 23149945, 23253910, 23345432, 23355489, 23365423, 23557743, 23610071, 23836881, 23873849, 23897892, 24220101, 24688021, 24748665, 25053826, 25495526, 25512560, 25525174, 25692509, 25714019, 25761368, 26057167, 26160886, 26578593, 26671524, 26765330, 26964895, 28132842, 29362359 |
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