| 产品详情 |
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| Product Name | Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) protein (His tag) |
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| Description | Ubiquitin Carboxyl-terminal Esterase L1 (UCH-L1), also known as PGP 9. 5, is a deubiquitinating enzyme with a predicted molecular weight of 25 kDa. The human protein shares 95% amino acid sequence identity with its mouse and rat orthologs. UCH-L1 is expressed abundantly in neurons, accounting for 1-2% of total soluble proteins in the brain. It localizes primarily to the cytoplasm, but a subpopulation has been shown to be transiently nuclear. UCH-L1 contains two catalytic residues, Cys90 and His161, which are required for isopeptide bond cleavage at the C-terminal glycine residue of ubiquitin. The levels of free ubiquitin appear to be partially regulated by UCH-L1 through the hydrolysis of small ubiquitin chains and the stabilization of monomeric ubiquitin. Mice lacking functional UCH-L1 show neuronal dysfunction and neurodegeneration, and mutations in this enzyme have been linked to Parkinson's disease, suggesting that it is important for proper central nervous system function. UCH-L1 also likely plays a complex role in cancer. It has been reported to function as an oncogene in lymphoma, colorectal cancer, and nonsmall cell lung carcinoma. In contrast, it is thought to function as a tumor suppressor protein in nasopharyngeal and breast cancers. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | cb358|wu:fc55h08|UCHL1|UCH-L1|park5|pgp9.5|uch-l1|MGC132191|uchl1|AW822034|C88048|PGP 9.5|PGP9.5|R75593|UCHL-1|gad|PARK5|PGP95|Uch-L1 |
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| Gene, Accession, CAS # | Gene ID: 22223 |
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| Catalog # | ABIN2745985 |
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| Order / More Info | Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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