| 产品详情 |
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| Product Name | Recombinant Human Retinoblastoma-like protein 2 (RBL2), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 27.4kDa. Partial: 417-616aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | 130 kDa retinoblastoma-associated protein (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) (RB2) |
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| Gene, Accession, CAS # | RBL2, UniProt: Q08999 |
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| Catalog # | RPC25775 |
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| Price | |
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| Order / More Info | Recombinant Human Retinoblastoma-like protein 2 (RBL2), partial from BIOMATIK |
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| Product Specific References | n/a |
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