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| Product Name | LCK, Active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase) |
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| Description | Purity ~90% (SDS-PAGE). Lck (p56lck) is a member of the src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show overexpression of Lck, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers. Colon cancers and T-cell leukemias frequently show defective regulation of Lck expression and activity. Inappropriate T cell activation and proliferation have been identified as an early event in auto-immune disease. Lck plays a prominent role in T-cell development, activation, proliferation and survival. Lck is coupled to both the CD4 and CD8 antigens (which serve as receptors for nonpolymorphic regions of products of the maj |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Active Lck, Lck, human Lck, active kinase, active kinases, recombinant Lck, recombinant Lck, kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | LCK, Gene ID: 3932, SwissProt: P06239 |
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| Catalog # | 219999 |
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| Order / More Info | LCK, Active, Recombinant, Human (Lymphocyte-specific Tyrosine Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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