| 产品详情 |
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| Antigenic Specificity | IRS-1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | 0.5 mg/ml |
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| Applications | Western blot, Immunohistochemistry |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRS-1 Antibody. IRS-1 (Insulin receptor substrate-1) is phosphorylated in response to stimulation of cells by insulin. Upon ligand-induced phosphorylation, IRS-1 immediately associates with a series of SH2 domain-containing signaling intermediates such as PI3-kinase, GRB2, Syp and Nck. The level of diversity in structure and function of the SH2-containing proteins which binds activated IRS-1 is important for responsiveness to insulin. IRS phosphorylation elicits the growth and metablic effects of insulin growth factors and insulin by allowing glucose uptake, glycogen synthesis and mitogenic activity. IRS-1 migrates between 170 and 185 kDa and is expressed in most cell types. |
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| Immunogen | Synthetic peptide mapping to the C-terminus of human IRS-1 |
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| Other Names | IRS1 , HIRS-1 |
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| Gene, Accession # | Gene ID: 3667, Accession: P35568 |
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| Catalog # | 3424-100 |
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| Price | |
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| Order / More Info | IRS-1 Antibody from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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