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| Product Name | Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-184), (AA 102-300) (Active) protein (Fc Tag) |
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| Description | Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3Molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-gamma and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA),which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.Recombinant human HVEM-Fc (rhHVEM-Fc) produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhHVEM-Fc has a molecular mass of around 45 kDa analyzed by reducing SDS-PAGE. Synonyms: TNFRSF14, TR2 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ATAR|CD270|HVEA|HVEM|LIGHTR|TR2|Atar|HveA|Hvem|Tnfrs14 |
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| Gene, Accession, CAS # | Gene ID: 8764 |
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| Catalog # | ABIN2017962 |
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| Order / More Info | Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-184), (AA 102-300) (Active) protein (Fc Tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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