| 产品详情 |
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| Product Name | W-MIF-1 (Tyr1) peptide |
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| Description | A novel tetrapeptide, Tyr-W-MIF-1(Tyr-Pro-Trp-Gly-NH2), was purified from extracts of frontal cortex of human brain tissue by several consecutive reversed-phase high performance liquid chromatographic steps followed by a radioimmunoassay originally developed for Tyr-Pro-Leu-Gly-NH2 (Tyr-MIF-1). Like Tyr-MIF-1, which was previously isolated from human brain tissue, Tyr-W-MIF-1 can inhibit the binding of 3H-DAMGO (selective for mu opiate receptors) to rat brain and can act as an opiate agonist as well as antagonist. Tyr-W-MIF-1 was a more potent opiate agonist than Tyr-MIF-1, the free acid of Tyr-W-MIF-1, and the structurally related hemoglobin-derived opiate peptide hemorphin-4 (Tyr-Pro-Trp-Thr) in the guinea pig ileum. Each of these peptides acted as opiate antagonists on the ileum from morphine-tolerant guinea pigs, the free acid of Tyr-W-MIF-1 was the most potent antagonist in inhibiting the activity of DAMGO. The presence in human brain of a new member of the Tyr-MIF-1 family of biologically active peptides. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN399913 |
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| Order / More Info | W-MIF-1 (Tyr1) peptide from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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