| 产品详情 |
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| Antigenic Specificity | ITGAV/Integrin Alpha V/CD51 |
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| Clone | NKI-M7 (former AMF7) |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, Flo, IHC, IHC-Fr, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ITGAV/Integrin Alpha V/CD51 Antibody (clone NKI-M7 (former AMF7)) LS-C347518. Specificity: T-lymphocyte clones NKI-M7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kD) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kD respectively. NKI-M7 reacts with cultured melanomas melanomas in frozen sections. The antigen detected by NKI-M7 is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. NKI-M7 blocks fibronectin-induced chemotactic motility and chemokinesis of melanoma cells. In addition to their membrane localization, the antigens detected by NKI-M7are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained. |
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| Immunogen | NKI-M7 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with cultured melanoma cells derived from a Human melanoma metastasis. |
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| Other Names | ITGAV, CD51, CD51 antigen, Integrin, alpha V, MSK8, Integrin Alpha V, Integrin alpha-V, VNRA, Vitronectin receptor, Integrin alphaVbeta3, VTNR |
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| Gene, Accession # | ITGAV, Gene ID: 3685 |
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| Catalog # | LS-C347518 |
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| Price | |
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| Order / More Info | ITGAV/Integrin Alpha V/CD51 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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