| 产品详情 |
| Edit |   |
|---|
| Product Name | GF-109203X |
|---|
| Description | MW: 412.5. Purity >99% (TLC); NMR (Conforms). PKC inhibitorInitially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR- (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation |
|---|
| Size | 1 mg, 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | [Sorafenib (base); 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide; BAY 43-9006 ] |
|---|
| Gene, Accession, CAS # | CAS: 133052-90-1 |
|---|
| Catalog # | MBS515025 |
|---|
| Price | |
|---|
| Order / More Info | GF-109203X from MYBIOSOURCE INC. |
|---|
| Product Specific References | 1. SM Wilhelm et al. Cancer Res. 2004 64:7099 2. J Guo et al. Mol. Cancer Ther. 2006 5:1007 3. SM Wilhelm et al. Proc. Am. Assoc. Cancer Res. 2003 44:106609 4. DJ Panka et al. Cancer Res. 2006 66:1611 |
|---|
| 产品资料 |
|
|