| 产品详情 |
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| Antigenic Specificity | CD23 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | fluorescein (FITC) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The CD23 antibody, clone EBVCS-5, is derived from the hybridization of Sp2/0 mouse myeloma cells with spleen cells from BALB/c mice immunized with an in vitro-transformed EBV cell line.The CD23 antibody recognizes a 45-kilodalton (kDa) type II membrane glycoprotein, which is a human B-lymphocyte differentiation antigen. The CD23 antigen is also known as the low affinity IgE receptor, Fc epsilon RII, and FcεRII. CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region. |
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| Immunogen | In vitro-transformed EBV cell line. |
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| Other Names | CD23; B6; BLAST-2; FceRII; Leu-20; Low affinity Ig3 receptor; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD23A; CLEC4J; FCE2; IGEBF; Low affinity immunoglobulin epsilon Fc receptor; CD antigen CD23) |
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| Gene, Accession # | Gene ID: 2208, SwissProt: P06734 |
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| Catalog # | abx200191 |
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| Order / More Info | CD23 Antibody from ABBEXA |
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| Product Specific References | n/a |
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