| 产品详情 |
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| Antigenic Specificity | Integrin alpha-L (ITGAL) |
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| Clone | M17-4 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | Protein A purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Functional Studies (Func),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunoprecipitation (IP),Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. |
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| Immunogen | C57BL/6 mouse splenic secondary cytotoxic T lymphocytes |
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| Other Names | (p180)|Cd11a|LFA-1|LFA-1A|Ly-15|Ly-21|CD11A|LFA1A|CD11a |
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| Gene, Accession # | Gene ID: 16408 |
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| Catalog # | ABIN457429 |
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| Price | |
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| Order / More Info | Integrin alpha-L (ITGAL) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16517703, 16011799, 11526097, 11222371, 6983917 |
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