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| Product Name | Recombinant Human Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 35.6kDa. Full Length of Isoform 2: 1-177aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SMUG1, UniProt: Q53HV7 |
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| Catalog # | RPC23130 |
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| Order / More Info | Recombinant Human Single-strand selective monofunctional uracil DNA glycosylase (SMUG1) from BIOMATIK |
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| Product Specific References | n/a |
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