| 产品详情 |
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| Antigenic Specificity | Notch 3 |
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| Clone | HMN3-133 |
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| Host Species | Armenian Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | purified |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-mouse Notch 3. The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome. |
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| Immunogen | Notch 3-Fc fusion protein |
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| Other Names | Neurogenic locus notch homolog protein 3, Notch-3, Notch3, CADASIL, CASIL |
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| Gene, Accession # | Gene ID: 18131 |
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| Catalog # | 130502 |
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| Price | |
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| Order / More Info | Notch 3 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 21536678,22274697 |
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