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| Product Name | Raphin 1 |
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| Description | Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase (Kd = 33 nM). Displays >30-fold selectivity for PPP1R15B over PPP1R15A. Inhibits PPP1R15B-mediated dephosphorylation and protein synthesis in vitro. Induces transient reduction in protein synthesis in brains of wild type mice after single dose. Decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in a mouse model of Huntington's disease. Orally bioavailable and brain penetrant. Purity 98%. MW (observed): 231.08 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide |
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| Gene, Accession, CAS # | CAS: 2022961-17-5 |
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| Catalog # | 6760/10 |
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| Price | |
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| Order / More Info | Raphin 1 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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