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| Product Name | EML4-ALK Mutant, Active |
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| Description | 1-496 (EML4) - 1058-end (ALK). MW: ~150 kDa. Description: Recombinant human fusion protein EML4 (1-496)-ALK (1058-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: ALK or CD246 is a receptor tyrosine kinase, which belongs to the insulin receptor superfamily, which comprises an extracellular domain, a hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. CD246 plays an important role |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay |
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| Other Names | [Homo sapiens mRNA for fusion protein EML4-ALK variant 1, complete cds; Tyrosine-protein kinase receptor] |
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| Gene, Accession, CAS # | EML4-ALK, Accession: AB274722 |
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| Catalog # | MBS515451 |
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| Order / More Info | EML4-ALK Mutant, Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Benharroch, D.et.al : ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91: 2076-2084, 1998. 2. Choi, Y. L. et.al: EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. New Eng. J. Med. 363: 1734-1739, 2010. |
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