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| Product Name | LMNA / Lamin A+C Protein (Recombinant His tag) |
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| Description | Purity >90% by SDS-PAGE, MW: 74.0 kDa. Recombinant Prelamin-A is a 74kDa precursor of the nuclear lamin A protein. Prelamin-A is a structural component of the nuclear lamina and it is encoded by lamin A/C gene (LMNA). Due to the presence of a CAAX box sequence at carboxyl terminus, Prelamin-A in vivo goes through a serial of post-translational modifications, resulting in the farnesylation of the cysteine thiol, removal of the AAX tripeptide, carboxyl-methylation of the cysteinyl carboxy group and proteolysis of 18 C-terminal amino acids residues that lead to mature lamin A. Diverse mutations in the lamin A/C gene are associated with different deseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Recombinant human prelamin A is fused to a 6 Histidine tag at the N-terminus. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LMNA, 70 kDa lamin, CDCD1, CMD1A, EMD2, FPLD, IDC, FPL, FPLD2, Lamin A/C, Lamin, LFP, LMNC, LMN1, LMNL1, HGPS, Prelamin-A/C, PRO1, Lamin A, Lamin A/C-like 1, LGMD1B, CDDC, CMT2B1, LDP1 |
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| Gene, Accession, CAS # | LMNA, Gene ID: 4000 |
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| Catalog # | LS-G20087 |
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| Order / More Info | LMNA / Lamin A+C Protein (Recombinant His tag) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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