| 产品详情 |
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| Antigenic Specificity | LIME |
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| Clone | LIME-10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LIME Monoclonal Antibody (LIME-10). LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals. |
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| Immunogen | n/a |
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| Other Names | Lck-interacting molecule, Lime1 |
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| Gene, Accession # | Entrez: 54923; Uniprot: Q9H400 |
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| Catalog # | MA1-19367 |
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| Price | |
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| Order / More Info | LIME Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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