| 产品详情 |
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| Antigenic Specificity | LIME |
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| Clone | mLIME-05 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: Assay Dependent, Western Blot: 1-5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LIME Monoclonal Antibody (mLIME-05). LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals. |
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| Immunogen | n/a |
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| Other Names | RP4-583P15.5, FLJ20406, LIME, LP8067, dJ583P15.4, lck-interacting membrane protein, lck-interacting molecule, lck-interacting transmembrane adapter 1 |
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| Gene, Accession # | Entrez: 72699; Uniprot: Q9EQR5 |
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| Catalog # | MA1-10399 |
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| Price | |
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| Order / More Info | LIME Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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