| 产品详情 |
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| Antigenic Specificity | TMEM59 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TMEM59 Polyclonal Antibody. Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding. |
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| Immunogen | n/a |
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| Other Names | RP4-758J24.2, C1orf8, HSPC001; liver membrane-bound protein |
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| Gene, Accession # | Entrez: 9528; Uniprot: Q9BXS4 |
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| Catalog # | PA5-21065 |
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| Price | |
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| Order / More Info | TMEM59 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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