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| Product Name | Recombinant Human Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 65.2kDa. Full Length: 1-540aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagent of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinaseRIP-like-interacting CLARP kinaseReceptor-interacting protein 2; RIP-2Tyrosine-protein kinase RIPK2 (EC:2.7.10.2) |
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| Gene, Accession, CAS # | RIPK2, UniProt: O43353 |
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| Catalog # | RPC21934 |
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| Order / More Info | Recombinant Human Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) from BIOMATIK |
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| Product Specific References | n/a |
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