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| Product Name | Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 49.4kDa. Partial: 1-375aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP; RIP, RIP1 |
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| Gene, Accession, CAS # | RIPK1, UniProt: Q13546 |
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| Catalog # | RPC23003 |
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| Order / More Info | Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1), partial from BIOMATIK |
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| Product Specific References | n/a |
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