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| Product Name | Recombinant Human Receptor-type tyrosine-protein phosphatase beta (PTPRB), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 57.4kDa. Cytoplasmic Domain: 1643-1997aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Plays an important role in blood vessel rodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and rodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel rodeling during bryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Vascular endothelial protein tyrosine phosphatase; VE-PTP |
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| Gene, Accession, CAS # | PTPRB, UniProt: P23467 |
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| Catalog # | RPC21883 |
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| Price | |
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| Order / More Info | Recombinant Human Receptor-type tyrosine-protein phosphatase beta (PTPRB), partial from BIOMATIK |
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| Product Specific References | n/a |
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