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| Product Name | Indomethacin N-octyl amide |
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| Description | Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.{1286} Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 values of indomethacin N-octyl amide for the inhibition of ovine COX-1 and human recombinant COX-2 are 66 µM and 40 nM, respectively, making it 1,650 times more potent as an inhibitor of COX-2 than COX-1.{8243} While indomethacin itself has an IC50 of 0.05 µM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 µM. |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | aromatic amides inhibitors inhibits COX-2 COX2 PGHS2 PGHS-2 prostaglandin synthases cyclooxygenases selective selectivity |
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| Gene, Accession, CAS # | CAS: 282728-65-8 |
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| Catalog # | 70273-10 |
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| Order / More Info | Indomethacin N-octyl amide from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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