| 产品详情 |
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| Product Name | PF 06463922 |
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| Description | High affinity and selective ALK and ROS1 inhibitor (Ki values are <0.02, <0.07 and 0.7 nM for ROS1, wild-type ALK and ALK-L1196M, respectively). Exhibits >100-fold selectivity for ROS1 over a panel of 204 other kinases. Inhibits proliferation of BaF3 cells containing crizotinib -resistant ROS1 mutation in vitro. Inhibits tumor growth in relevant mouse models. Orally available and brain penetrant. Purity 98%. MW (observed): 406.41 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile. Lorlatinib |
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| Gene, Accession, CAS # | CAS: 1454846-35-5 |
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| Catalog # | 5640/10 |
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| Price | |
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| Order / More Info | PF 06463922 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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