| 产品详情 |
| Edit |   |
|---|
| Product Name | PF 3644022 |
|---|
| Description | Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models. Purity 98%. MW (observed): 374.46 |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one |
|---|
| Gene, Accession, CAS # | CAS: 1276121-88-0 |
|---|
| Catalog # | 4279/10 |
|---|
| Price | |
|---|
| Order / More Info | PF 3644022 from TOCRIS BIOSCIENCE
|
|---|
| Product Specific References | PubMed: 26017782, 28506461 |
|---|
| 产品资料 |
|
|