| 产品详情 |
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| Antigenic Specificity | JAK2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human (predicted: hamster) |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100ug (sample available) |
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| Concentration | 500ug/ml. |
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| Applications | IF, IHC-P, ICC, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal antibody for Tyrosine-protein kinase JAK2(JAK2) detection. Tested with WB, IHC-P, ICC/IF in Human. No cross reactivity with other proteins. Janus kinase 2, commanly called JAK2, is a human protein that has been implicated in signaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. Exactly, JAK2 kinase is a member of a family of tyrosine kinases involved in cytokine receptor signaling. The JAK2 gene is mapped to 9p24.1. The JAK2 gene encodes a 1,132-amino acid protein that shares 95% sequence similarity to rat and pig Jak2. JAK2 is constitutively associated with the prolactin receptor and that it is activated and tyrosine phosphorylated upon PRL binding to the PRL receptor. JAK2, and more specifically just its intact N-terminal domain, binds to EPOR in the endoplasmic reticulum and promotes its cell surface expression. The human JAK2 is present in the nucleus of hematopoietic cells and directly phosphorylates tyr41 on histone H3. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human JAK2(1096-1113aa DEIYMIMTECWNNNVNQR). |
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| Other Names | Tyrosine-protein kinase JAK2;2.7.10.2;Janus kinase 2;JAK-2;JAK2; |
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| Gene, Accession # | JAK2, UniProt: O60674 |
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| Catalog # | PA1629 |
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| Price | |
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| Order / More Info | JAK2 Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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