| 产品详情 |
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| Antigenic Specificity | ESET, internal |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunoaffinity purified |
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| Size | 100 µg |
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| Concentration | 1.17 mg/mL |
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| Applications | ELISA, Immunohistochemistry, Western Blot. This affinity purified antibody has been tested for use in ELISA and western blotting. Western blotting shows reactivity specific for human ESET detecting a band at approximately 170 kDa. Specific band detection by western blot is blocked by peptide competition by pre-incubating the antibody with the immunizing peptide prior to reaction with the membrane. Reactivity in other immunoassays is unknown. |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase. Reactivity occurs against human ESET protein. |
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| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1058-1075 of human ESET. |
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| Other Names | rabbit anti-ESET antibody, ERG-associated protein with SET domain, rabbit anti-SETDB1 antibody, SETDB-1, SETDB 1, Histone lysine N methyltransferase antibody, Histone-lysine N-methyltransferase SETDB1 antibody, KMT1E antibody, Lysine N-methyltransferase 1E antibody, SET domain bifurcated 1, H3-K9-HMTase 4, Histone H3-K9 methyltransferase 4 |
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| Gene, Accession # | SETDB1, Gene ID: 9869, NCBI: 224177469, UniProt: Q15047 |
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| Catalog # | 600-401-689 |
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| Price | |
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| Order / More Info | ESET, internal Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | Schultz D.C., Ayyanathan K., Negorev D., Maul G.G., Rauscher F.J. III, (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16:919-932(2002).Sarraf,S.A. and Stancheva,I. (2004) Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol. Cell 15 (4), 595-605.Wang,H., An,W., Cao,R., Xia,L., Erdjument-Bromage,H., Chatton,B., Tempst,P., Roeder,R.G. and Zhang,Y. (2003) mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12 (2), 475-487.Harte,P.J., Wu,W., Carrasquillo,M.M. and Matera,A.G. (1999) Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids. Cytogenet. Cell Genet. 84 (1-2), 83-86. |
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