| 产品详情 |
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| Product Name | GW 4869 (hydrochloride hydrate) |
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| Description | An inhibitor of neutral sphingomyelinase (IC50 = 1 µM); selective for neutral sphingomyelinase over acid sphingomyelinase at concentrations up to 150 µM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 µM; inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells; reduces the inhibitory effects of OxPAPC and KOdiA-PE on LPS-induction of IL-8 in human aortic endothelial cells; reverses hypoxia-induced pulmonary vasoconstriction in rats at 1 mg/kg, |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | inhibitors sphingomyelin sphingomyelinase neutral acidic TNF-α ceramides cells death GW4869 gw-4869 Bacillus PCPLC GW4869 IL8 MCF7 PP-2A lysoPAF |
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| Gene, Accession, CAS # | CAS: 6823-69-4 |
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| Catalog # | 13127-10 |
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| Order / More Info | GW 4869 (hydrochloride hydrate) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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