| 产品详情 |
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| Product Name | ML 786 dihydrochloride |
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| Description | Potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively). Also inhibits Abl-1, DDR2, EPHA2 and RET tyrosine kinase activity. Inhibits pERK formation and attenuates tumor growth in melanoma cell xenografts expressing the B-RafV600E mutation in vivo. Orally bioavailable. Purity 98%. MW (observed): 611.48 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamide dihydrochloride. BGB659 |
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| Gene, Accession, CAS # | CAS: 1237536-18-3 |
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| Catalog # | 5036/10 |
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| Order / More Info | ML 786 dihydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 30045926 |
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| 产品资料 |
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