| 产品详情 |
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| Product Name | SAG |
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| Description | Potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. Potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins. Putative inhibitor of a cellular component required for Hedgehog signaling. Enhances neuronal differentiation of iPSCs into dopaminergic neurons. Purity 99%. MW (observed): 490.06 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide |
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| Gene, Accession, CAS # | CAS: 912545-86-9 |
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| Catalog # | 4366/1 |
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| Order / More Info | SAG from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 26365513, 26842779 |
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| 产品资料 |
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