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| Product Name | COL4A2, Recombinant, Human, aa1493-1712, His-Tag (Collagen alpha-2(IV) Chain) |
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| Description | Purity ~90% (SDS-PAGE). Type IV collagen is the major structural component of glomerular basent membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Source: Recombinant protein corresponding to aa1493-1712 from human COL4A2, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~28.3kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P08572 |
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| Catalog # | 372827 |
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| Order / More Info | COL4A2, Recombinant, Human, aa1493-1712, His-Tag (Collagen alpha-2(IV) Chain) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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