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| Product Name | Interleukin-36 gamma, active (IL36G), Recombinant, Human |
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| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activat |
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| Size | 2ug, 10ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL-1-related protein 2, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 9, IL-1F9 |
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| Gene, Accession, CAS # | IL36G_HUMAN, SwissProt: Q9NZH8 |
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| Catalog # | 348136 |
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| Order / More Info | Interleukin-36 gamma, active (IL36G), Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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